Broadly speaking, I am interested in genome sequencing and its future role in our daily lives. With the age of rapidly decreasing sequencing costs, it is not difficult to imagine an age where personal genetic information plays an important role in medicine and daily life. (Note: If you’re at this site and totally confused as to what I’m talking about, I highly recommend watching this low-technical-level Primer on Genomics by my advisor, Mike Snyder). We are constantly discovering more and more of the genetic basis of diseases, but much work has yet to be done in fully explaining the genetic components of disease and other phenotypes.

In my current research, I am interested in gene regulation at a genome-wide scale. While I have had a soft spot for all layers of regulation (DNA, RNA and protein levels), my current research is primarily focused on regulation of gene expression at the transcriptional (DNA) level. Using ChIP-Seq methods in human cell lines and sophisticated informatics methods, I am working to characterize interactions between transcription factors.

Advertisements


RSS Recent Publications

  • Quantifying the Impact of Rare and Ultra-rare Coding Variation across the Phenotypic Spectrum. Ganna A, Satterstrom FK, Zekavat SM, Das I, Kurki MI, Churchhouse C, Alfoldi J, Martin AR, Havulinna AS, Byrnes A, Thompson WK, Nielsen PR, Karczewski KJ, Saarentaus E, Rivas MA, Gupta N, Pietiläinen O, Emdin CA, Lescai F, Bybjerg-Grauholm J, Flannick J, GoT2D/T2D-GENES Consortium, Mercader JM, Udler M, SIGMA Consortium Helmsley IBD Exome Sequencing Project, FinMetSeq Consortium, iPSYCH-Broad Consortium, Laakso M, Salomaa V, Hultman C, Ripatti S, Hämäläinen E, Moilanen JS, Körkkö J, Kuismin O, Nordentoft M, Hougaard DM, Mors O, Werge T, Mortensen PB, MacArthur D, Daly MJ, Sullivan PF, Locke AE, Palotie A, Børglum AD, Kathiresan S, Neale BM

Twitter

  • RT @Eric_Fauman: Ah; something genome wide significant and some real biology! rs16837545 on chr1, pvalue 9e-9. Not in any previously desc… 3 weeks ago
  • RT @michaelhoffman: KJ: Human site frequency spectrum not accurately explained by infinite sites model (= no recurrent mutation). #probgen11 month ago
  • RT @GeneticsSociety: Congrats to our 2018 Epstein Awardees! These trainees worked hard on their research, and presented it well at #ASHG18!… 1 month ago
  • RT @SuomenBiopankit: Suomalaiset biopankit vahvasti mukana #FinnGen F2F kokouksessa Helsingissä! Kaksi päivää mielenkiintoisia esityksiä ja… 1 month ago
  • RT @B_resnick: Genetics research is overwhelmingly conducted on white participants of European ancestry. That's a big problem for medicine.… 1 month ago
Advertisements

%d bloggers like this: